Abstract
We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Line
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Glutathione / metabolism
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Glutathione / pharmacology*
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Humans
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Interferon-gamma / pharmacology
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Lipopolysaccharides / pharmacology
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Macrophage Activation
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Macrophages / immunology*
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Macrophages / microbiology*
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Mice
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / growth & development*
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S-Nitrosoglutathione / pharmacology*
Substances
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Lipopolysaccharides
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S-Nitrosoglutathione
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Interferon-gamma
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Glutathione