Abstract
Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼ 3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼-25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.
Keywords:
PGC-1α; energetic stress; exercice par intervalle d’intensité élevée; high-intensity interval exercise; stress énergétique.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adult
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Bicycling
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Brain-Derived Neurotrophic Factor / agonists*
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Brain-Derived Neurotrophic Factor / genetics
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Brain-Derived Neurotrophic Factor / metabolism
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Cross-Over Studies
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Exercise*
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Fasting / adverse effects*
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Gene Expression Regulation*
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Humans
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Male
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Motor Activity
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Muscle, Skeletal / metabolism*
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Muscle, Skeletal / physiology
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Oxygen Consumption
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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Physical Exertion
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Quadriceps Muscle / metabolism
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Quadriceps Muscle / physiology
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RNA, Messenger / metabolism*
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Stress, Physiological*
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Transcription Factors / agonists
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Up-Regulation
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Young Adult
Substances
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Brain-Derived Neurotrophic Factor
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PPARGC1A protein, human
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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RNA, Messenger
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Transcription Factors
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BDNF protein, human