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Research funding: None declared.
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Author contribution: F. Di Mario and P. Crafa,: study design, writing of the manuscript, supervision. K. Rodriguez-Castro, M. Franceschi, M. Russo, L. Franzoni: clinical data collection and analysis of the literature. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: The research had followed the tenets of the Helsinki Declaration and the study was performed following the declaration of Helsinki and approved by the local Ethics Committee (Identifier: 92687).
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